Bilateral Hippocampal Sclerosis
•Not infrequently, hippocampal sclerosis affects both hippocampi           .
•    Due to this fact, visual analysis of potential signal changes of the hippocampus must be done not only by comparison with the contralateral hippocampus, but also with the ipsilateral cortical grey matter of the temporal lobe.
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Figure 23. Bilateral hippocampal sclerosis. Coronal fast-SE T2W MRI in a patient with intractable temporal lobe epilepsy, who demonstrates bilateral hippocampal sclerosis. Observe the symmetrical signal intensity and volume of the hippocampi. However, their signal intensity is clearly increased in comparison with the cortical grey matter of the temporal lobe.
Figure 22. Unilateral hippocampal sclerosis. Coronal fast-SE T2WI obtained in a patient with intractable temporal lobe epilepsy, demonstrates high signal intensity and decreased volume of the right hippocampus (left). Note also a slightly enlarged temporal horn. Compare these findings with a normal hippocampus (right).
(Fig. 23)