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Lupus Central Nervous System Vasculitis
Circulatory Pathology Demonstrated with Perfusion MR Imaging
  • Julien PEYRE
  • in collaboration with Dr J.K.SMITH
  • (julien.peyre@cpe.fr)
  • The University of North Carolina
  • at Chapel Hill
  • supported in part by the UNC CFAR
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Goal
  • Compare a population of Lupus patients with a normal population
    • Lupus population : 9 patients
    • Normal population : 10 patients
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Technical goal
  • Create 4 atlases for each population :
    • 2 for the CBV images :
      • 1 grey matter atlas.
      • 1 white matter atlas.
    • 2 for the CBF images:
      • 1 grey matter atlas.
      • 1 white matter atlas.


  • Thanks to the atlases we will be able to compare the different populations. The atlases need to be registered to a reference to allow the comparison. Our reference will be a Phantom.
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Technical goal
  • Separating the white and grey matter we avoid the overlapping between white and grey matter. We don’t want to sum white matter with grey matter.
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Current method
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Current Method
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Statistical analysis of the results
  • To compare the two populations we use two different statistical tools :
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Zscore
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Future Work
  • This atlas based comparison technique may be useful for studying a wide range of circulatory pathology.
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