Model for exploration of
Wallerian degeneration
•The tissue
responses to definitive brain ischemia are characterized by selective neuronal injury with consequent cascade of encephalomalacia, coagulation necrosis, fluid-filled cavity
•The end phases
of an ischemic infarct and a diffuse axonal injury resemble each other
•In large
infarcts involving the cortex or its fiber, secondary degeneration of corticospinal fibers will occur with a consequent reduction in size (with asymmetry) of the cerebral peduncle, pons, and corticospinal tracts