Clean Up

Vol. 2, Issue 2, Article 1

Radaideh, et al.

Clean up

Irreversible cell injury and cellular rupture are associated with the release of cellular components, production of cytokines and increased expression of adhesion molecules.
These agents recruit circulating polymorphnuclear leukocytes (PMNs) and macrophages to phagocytize the cellular remnants and replace them with fibrotic tissue (gliosis). Gliosis is composed mainly of interstitial fluid and has high diffusibility.

[image 10a]

Title Page

Purpose and Introduction

Hypoxic neuronal injury

Metabolic neuronal derangements secondary to hypoxia

Low intracellular O2 tension results in low ATP# concentration which leads to increased ADP*

Intracellular calcium and loss of calcium homeostasis and sustained rise in intracellular Ca2+

Irreversible cell injury

Clean up

How quickly does the hypoxic neuronal damage happen?

MRI Correlation

I. Hemodynamic correlation

II. Metabolic correlation

III. Histopathologic correlation

III. Histopathologic correlation (con't)

Conclusion

References

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