Irreversible cell injury

Vol. 2, Issue 2, Article 1

Radaideh, et al.

Irreversible cell injury

After the initiation of irreversible death, the cell and its organelles start to disintegrate, leading to rupture of the cells.
Gradually, the cytotoxic edema starts to resolve and interstitial edema develops as the cell membranes disintegrate and the intracellular components become extracellular.
This results in increased Brownian water motion and marked reduction in diffusion restriction.
The neuronal death result in reduction of its markers (NAA).

[image 9a]

[image 9b]

Title Page

Purpose and Introduction

Hypoxic neuronal injury

Metabolic neuronal derangements secondary to hypoxia

Low intracellular O2 tension results in low ATP# concentration which leads to increased ADP*

Intracellular calcium and loss of calcium homeostasis and sustained rise in intracellular Ca2+

Irreversible cell injury

Clean up

How quickly does the hypoxic neuronal damage happen?

MRI Correlation

I. Hemodynamic correlation

II. Metabolic correlation

III. Histopathologic correlation

III. Histopathologic correlation (con't)

Conclusion

References

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