Title

Vol. 2, Issue 2, Article 1

Radaideh, et al.

Correlating the Basic Chronological Pathophysiologic Neuronal Changes in Response to Ischemia with Multisequence MRI Imaging.

Majdi Radaideh, MD.
Catherine Devine, MD.
Don Schomer, MD. ‡
Ashok J. Kumar, MD. ‡
Edwin Cacayorin, MD.*
Joon Song, MD *
Steve Lutzker, M.D.*
Norman Leeds, MD. ‡

‡Department of Radiology, The University of Texas MD Anderson Cancer Center, Houston, TX.
*Department of Radiology, The University of Texas Medical School at Houston, Houston, TX

Originally presented as a scientific exhibit at the 40th Annual Meeting of the ASNR, Vancouver, Canada, May 13-17, 2002.

Title Page

Purpose and Introduction

Hypoxic neuronal injury

Metabolic neuronal derangements secondary to hypoxia

Low intracellular O2 tension results in low ATP# concentration which leads to increased ADP*

Intracellular calcium and loss of calcium homeostasis and sustained rise in intracellular Ca2+

Irreversible cell injury

Clean up

How quickly does the hypoxic neuronal damage happen?

MRI Correlation

I. Hemodynamic correlation

II. Metabolic correlation

III. Histopathologic correlation

III. Histopathologic correlation (con't)

Conclusion

References

Copyright © 2003. All rights reserved.
Use of this material without written consent of the author is prohibited.

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